Rifabutin

Category: pharmacological

Aliases: Mycobutin

Pharmacological Mechanism

Spiropiperidyl rifamycin — narrower CYP3A4 induction than rifampin, used in HIV+TB co-treatment where rifampin would crater PI levels. Still meaningfully induces CYP3A4 (~40% AUC reduction of co-administered substrates).

Half-Life (t½)

PO: 36h

Dosing Guidelines

• PO: Typical 300mg (Range: 150 - 300 mg)

Target Organ Systems

• digestive

Interactions

• Buprenorphine