Category: peptide
Aliases: LY3437943, GLP-3, triple agonist
Triple agonist at GLP-1R, GIP-R, and glucagon receptor. 39-residue peptide with Aib substitutions (positions 2 and 20) and a C-20 fatty diacid linker on Lys(17) via a γGlu-2×OEG spacer that binds albumin, extending t½ into once-weekly territory. Glucagon arm drives additional energy expenditure beyond GLP-1/GIP satiety effects.
SC: 144h