Category: polyphenol
Aliases: trans-Resveratrol, 3,5,4'-trihydroxystilbene
Direct [[nad_sirtuin_axis]] SIRT1 activator at high concentrations (disputed — some studies show fluorophore artifact). Also activates [[ampk_signaling]], inhibits PDE4, and is a weak ER-α ligand. Extensively glucuronidated + sulfated — plasma aglycone concentration is low even at gram doses. Commonly paired with [[nmn]] in 'longevity' stacks.
PO: 9h