Dimethyl ether analog of resveratrol — the two 3,5 methoxy groups block glucuronidation, giving much better systemic exposure. Shares SIRT1 activation and AMPK stimulation with resveratrol but at lower doses. Small RCTs show modest LDL reduction at 125 mg/d.
Half-Life (t½)
PO: 100h
Dosing Guidelines
PO: Typical 117 mg (Range: 50–250 mg)
Target Organ Systems
cardiovascular
Interactions
Resveratrol (synergistic): Both stilbenoids — pterostilbene is a higher-bioavailability analog. Typically pick one.