Pantethine

Category: vitamin

Aliases: Bis-pantethine disulfide, Activated B5

Pharmacological Mechanism

Dimeric disulfide form of pantetheine, the immediate CoA precursor (one step from CoA vs. three from pantothenic acid). Proposed dyslipidemia mechanism is inhibition of HMG-CoA reductase and acyl-CoA:cholesterol acyltransferase (ACAT) at the pantetheine stage.

Half-Life (t½)

PO: 0.067h

Dosing Guidelines

• PO: Typical 500 mg (Range: 300–900 mg)

Target Organ Systems

• cardiovascular

Interactions

• Pantothenic acid (B5) (synergistic): Both feed the CoA pool; pantethine is closer to CoA, pantothenate is cheaper. No need to co-supplement.

Pathways It Modulates

• Niacin / NAD+ biosynthesis (substrate) — pantothenic acid precursor (CoA synthesis)

Chemical Identifiers

• PubChem CID: 452306
• Formula: C22H42N4O8S2
• Molecular weight: 554.72 g/mol
• InChIKey: DJWYOLJPSHDSAL-ROUUACIJSA-N
• SMILES: CC(C)(CO)[C@H](C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO)O)O

References

• PMID 21925346
• PMID 4056044