Magnesium Orotate

Category: mineral

Pharmacological Mechanism

Mg²⁺ chelated to orotic acid. Lower elemental-Mg content (~7%) but the orotate moiety is a pyrimidine-synthesis intermediate sometimes claimed to enhance cardiac uptake. Trialed in HFrEF (Stepura 2009) with modest mortality signal — replication is limited.

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 3000mg (Range: 1500 - 6000 mg)

Target Organ Systems

• cardiovascular