Category: peptide
Aliases: Somatuline Autogel, Somatuline Depot, BIM-23014
Cyclic octapeptide somatostatin analog (D-βNal substituted for D-Phe vs. octreotide) with SSTR2 and SSTR5 agonist activity. Autogel is a supersaturated aqueous formulation that forms an extended-release deep-SC depot — no oil vehicle or polymer microspheres required. Indications mirror octreotide: acromegaly (GH / IGF-1 suppression), functional NET symptom control, anti-proliferative effect (CLARINET trial — PFS benefit in non-functioning midgut + pancreatic NET).
SC: 600h