Kisspeptin-10

Category: peptide

Aliases: Metastin 45-54, KP-10

Pharmacological Mechanism

C-terminal 10-aa fragment of kisspeptin (positions 45-54 of the 54-mer). Equivalent KISS1R affinity + potency to full-length kisspeptin — the RF-amide motif at the C-terminus carries the binding epitope. Same clinical applications (GnRH induction, reproductive research) with easier synthesis.

Target Organ Systems

• endocrine

Interactions

• Kisspeptin (synergistic): Kisspeptin-10 is the minimum-active C-terminal fragment, equivalent KISS1R potency. Pick one.

Pathways It Modulates

• GnRH pulse generator (activator) — KISS1R (KP-10 minimum agonist)

Chemical Identifiers

• PubChem CID: 25240297
• Formula: C63H83N17O14
• Molecular weight: 1302.4 g/mol
• InChIKey: RITKWYDZSSQNJI-INXYWQKQSA-N
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC5=CC=C(C=C5)O)N