Kisspeptin

Category: peptide

Aliases: Metastin, KISS1 gene product

Pharmacological Mechanism

Upstream master regulator of GnRH release — activates KISS1R (GPR54) on hypothalamic GnRH neurons. Critical for reproductive-axis initiation (puberty) and maintenance. Proposed clinical uses include hypogonadotropic hypogonadism, IVF ovulation trigger (bypasses some HCG safety concerns), and PCOS research.

Half-Life (t½)

IV: 0.46h

Target Organ Systems

• nervous
• endocrine
• reproductive

Interactions

• Kisspeptin-10 (synergistic): Kisspeptin-10 is the minimum-active C-terminal fragment, equivalent KISS1R potency. Pick one.

Pathways It Modulates

• GnRH pulse generator (activator) — KISS1R

Chemical Identifiers

• PubChem CID: 71306396
• Formula: C258H401N79O78
• Molecular weight: 5857 g/mol
• InChIKey: KAHDONZOCXSKII-NJVVDGNHSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC7=CC=CC=C7)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=CC=C8)C(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC9=CN=CN9)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)CN

References

• PMID 26192876