Category: flavonoid
Aliases: Hesperetin-7-O-rutinoside, Hesperetin rutinoside
Rutinoside (rhamnose-glucose) of the flavanone hesperetin. Cannot be absorbed intact — colonic microbial α-rhamnosidase + β-glucosidase cleave the sugar moieties, liberating hesperetin aglycone that is then glucuronidated in the enterocyte/liver and enters systemic circulation as conjugates (Tmax 5–7 h). Endothelium-directed effects are mediated by hesperetin conjugates: eNOS upregulation, lower ICAM-1/VCAM-1, modestly improved FMD in RCTs (Cochrane 2019).
PO: 8h