GHRP-2

Category: peptide

Aliases: Pralmorelin, KP-102

Pharmacological Mechanism

GHSR-1a agonist with dual ghrelin-mimetic activity — drives GH release AND raises cortisol/prolactin modestly (less selective than ipamorelin). Historically the Rx GH-stimulation-test agent in Japan.

Half-Life (t½)

SC: 0.55h

Dosing Guidelines

• SC: Typical 167 mcg (Range: 100–300 mcg)
• IN: Typical 167 mcg (Range: 100–300 mcg)

Target Organ Systems

• endocrine

Interactions

• Ipamorelin (synergistic): Same GHSR-1a target, different selectivity profile. Stacking redundant.

Pathways It Modulates

• Growth hormone / GHRH / GHS axis (activator) — GHS-R1a (ghrelin receptor agonist)

Chemical Identifiers

• PubChem CID: 6918245
• Formula: C45H55N9O6
• Molecular weight: 818 g/mol
• InChIKey: HRNLPPBUBKMZMT-RDRUQFPZSA-N
• SMILES: C[C@H](C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCCN)C(=O)N)N

References

• PMID 9879640
• PMID 9092793
• PMID 9543135