Gemfibrozil

Category: pharmacological

Aliases: Lopid

Pharmacological Mechanism

Older PPARα agonist — similar TG/HDL profile to fenofibrate. Problematic CYP2C8 inhibition → raises statin levels → substantial rhabdomyolysis signal. Fenofibrate preferred in statin combinations for this reason.

Half-Life (t½)

PO: 1.5h

Dosing Guidelines

• PO: Typical 600mg (Range: 600 - 600 mg)

Target Organ Systems

• cardiovascular
• digestive

Interactions

• Simvastatin / statins
• Repaglinide
• Cerivastatin
• Montelukast
• Pioglitazone
• Rosiglitazone
• Loperamide