Pioglitazone

Category: pharmacological

Aliases: Actos

Pharmacological Mechanism

Thiazolidinedione — PPAR-γ agonist; sensitizes muscle, adipose, and liver to insulin. CYP2C8 substrate (gemfibrozil DDI). Weight gain + edema; bladder cancer signal in some studies; bone loss.

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 30mg (Range: 15 - 45 mg)

Target Organ Systems

• endocrine
• digestive
• renal
• musculoskeletal