Omega-3 (EPA/DHA)

Category: lipid

Aliases: Fish oil, EPA + DHA, omega3, omega-3-epa-dha, fish oil, epa, dha

Pharmacological Mechanism

Long-chain ω-3 PUFAs. Incorporate into phospholipid membranes → altered fluidity + eicosanoid precursor shift away from arachidonic acid. EPA → resolvins E-series; DHA → protectins + resolvins D-series (pro-resolution lipid mediators). REDUCE-IT trial 2019 demonstrated CV event reduction with 4 g/day EPA ethyl ester; mixed-EPA-DHA trials have been less consistently positive.

Half-Life (t½)

PO: 46h

Dosing Guidelines

Target Organ Systems

Interactions