Category: vitamin
Aliases: Vitamin B12, Synthetic B12
Cobalamin with a cyanide ligand at the central cobalt — must be dealkylated by cyanocobalamin reductase and reduced to cob(II)alamin before conversion to methylcobalamin (cytosol) or adenosylcobalamin (mitochondrion), the two active coenzyme forms. Oral absorption requires gastric intrinsic factor (IF) + ileal cubilin/amnionless uptake — saturable at ~1.5 mcg per dose; passive diffusion at ~1% above that.
PO: 144h