Ciprofloxacin

Category: pharmacological

Aliases: Cipro

Pharmacological Mechanism

Fluoroquinolone — inhibits bacterial DNA gyrase + topoisomerase IV. Strong CYP1A2 inhibitor (raises caffeine, theophylline, tizanidine, clozapine). Black-box: tendinopathy + Achilles rupture, peripheral neuropathy, aortic aneurysm.

Half-Life (t½)

PO: 4h, IV: 4h

Dosing Guidelines

• PO: Typical 500mg (Range: 250 - 750 mg)

Target Organ Systems

• digestive
• musculoskeletal

Interactions

• Theophylline
• Tizanidine
• Caffeine
• Ropivacaine
• Clozapine