Tizanidine

Category: pharmacological

Aliases: Zanaflex

Pharmacological Mechanism

Centrally-acting α2-adrenergic agonist — reduces presynaptic excitatory neurotransmitter release in spinal cord interneurons → less muscle tone. Used for spasticity. CYP1A2 substrate — ciprofloxacin / fluvoxamine + tizanidine = severe hypotension (boxed warning).

Half-Life (t½)

PO: 2.5h

Dosing Guidelines

• PO: Typical 8mg (Range: 2 - 36 mg)

Target Organ Systems

• nervous
• digestive