Category: nucleotide
Aliases: Adenosine monophosphate, 5'-AMP
Endogenous energy-sensor. AMP/ATP ratio activates AMPK — the master energy-stress kinase switching catabolism on and anabolism off. Formed from ATP hydrolysis (via myokinase) or de-novo purine synthesis. Substrate for NAD⁺ biosynthesis via NMNAT (NMN + ATP → NAD⁺ + PPi).