PCSK9

Proprotein convertase, regulates cholesterol homeostasis.

Key Functions:

• Degrades LDL receptors.
• Modulates plasma cholesterol levels.

Interacting Systems & Components:

• Metabolic System (cholesterol regulation)
• LDLR (target receptor)
• Hepatocyte (expression site)

Gene Record

Approved symbol: PCSK9

Approved name: proprotein convertase subtilisin/kexin type 9

Locus: 1p32.3

Locus type: gene with protein product

HGNC: HGNC:20001

From the HGNC naming authority.