Zonisamide

Category: pharmacological

Aliases: Zonegran

Pharmacological Mechanism

Sulfonamide antiseizure — Na+ + T-type Ca²⁺ channel blocker, weak carbonic anhydrase inhibition. Adjunct for partial seizures + off-label migraine prophylaxis + weight-loss adjunct (Qsymia precursor mechanistic relative).

Half-Life (t½)

PO: 63h

Dosing Guidelines

• PO: Typical 200mg (Range: 100 - 600 mg)

Target Organ Systems

• nervous
• immune-hematologic