Zolpidem

Category: sleep

Aliases: Ambien, Stilnox

Pharmacological Mechanism

Non-benzodiazepine α1-selective GABA-A PAM (the α1 subunit drives hypnosis; avoiding α2/α3 minimises anxiolytic/myorelaxant effects). Rapid onset + short t½ for sleep-onset indication.

Half-Life (t½)

PO: 2.4h

Dosing Guidelines

• PO: Typical 6.67mg (Range: 5 - 10 mg)
• SL: Typical 6.67mg (Range: 5 - 10 mg)

Target Organ Systems

• nervous