Ziprasidone

Category: pharmacological

Aliases: Geodon, Zeldox

Pharmacological Mechanism

Atypical antipsychotic; potent D2 / 5-HT2A antagonist. Notable for a clinically significant food effect (oral absorption ~doubles with a ≥500 kcal meal) and QT prolongation (hERG block). Oral + IM (acute agitation).

Half-Life (t½)

PO: 7h, IM: 3h

Dosing Guidelines

• PO: Typical 80 mg (Range: 40–160 mg)
• IM: Typical 20 mg (Range: 10–40 mg)

Target Organ Systems

• nervous

Chemical Identifiers

• PubChem CID: 60854
• Formula: C21H21ClN4OS
• Molecular weight: 412.94 g/mol
• InChIKey: MVWVFYHBGMAFLY-UHFFFAOYSA-N
• SMILES: C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54

References

• PMID 10771448
• PMID 16231965
• PMID 9430133
• PMID 12176106
• PMID 9760039
• PMID 12629531
• PMID 8935801