Zinc Pyrithione

Category: topical

Aliases: Head and Shoulders active

Pharmacological Mechanism

OTC antiseborrheic shampoo active at 1–2%. Antifungal against Malassezia + cytostatic against keratinocyte hyperproliferation. EU restrictions emerging on environmental + safety grounds.

Half-Life (t½)

TD: 24h

Dosing Guidelines

• TD: Typical 10mg (Range: 10 - 20 mg)

Target Organ Systems

• integumentary
• immune-hematologic