Zileuton

Category: pharmacological

Aliases: Zyflo

Pharmacological Mechanism

5-lipoxygenase inhibitor — blocks leukotriene biosynthesis upstream of CysLT1 receptor. Asthma maintenance; less used than montelukast. CYP1A2 inhibitor (raises theophylline + propranolol). Hepatotoxicity warning requires LFT monitoring.

Half-Life (t½)

PO: 2.5h

Dosing Guidelines

• PO: Typical 1200 mg (Range: 600–2400 mg)

Target Organ Systems

• respiratory
• digestive

Pathways It Modulates

• Asthma (inhibitor) — 5-lipoxygenase (upstream leukotriene synthesis)
• Mast cell stabilization + leukotriene axis (inhibitor) — 5-lipoxygenase (LT biosynthesis)

Chemical Identifiers

• PubChem CID: 60490
• Formula: C11H12N2O2S
• Molecular weight: 236.29 g/mol
• InChIKey: MWLSOWXNZPKENC-UHFFFAOYSA-N
• SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O

References

• PMID 8620668