Zaleplon

Category: pharmacological

Aliases: Sonata, Starnoc

Pharmacological Mechanism

Z-drug pyrazolopyrimidine — positive allosteric modulator at GABA-A BZD site, selective for α1 subunit. Used for sleep onset (very short t½ ~1 h limits middle-of-night dosing risk). Mostly metabolized by aldehyde oxidase + CYP3A4. Rapid absorption.

Half-Life (t½)

PO: 1.05h

Dosing Guidelines

• PO: Typical 10mg (Range: 5 - 20 mg)

Target Organ Systems

• nervous