Zafirlukast

Category: pharmacological

Aliases: Accolate

Pharmacological Mechanism

CysLT1 receptor antagonist — same target as montelukast but BID dosing + meaningful CYP2C9 inhibition (raises warfarin INR). Hepatotoxicity warning; less prescribed than montelukast.

Half-Life (t½)

PO: 10h

Dosing Guidelines

• PO: Typical 20mg (Range: 20 - 20 mg)

Target Organ Systems

• digestive