Yohimbine

Category: alkaloid

Aliases: Quebrachine

Pharmacological Mechanism

α₂-adrenergic receptor antagonist — blocks the pre-synaptic α₂ autoreceptor that normally brakes noradrenaline release → elevates sympathetic tone, noradrenaline, and lipolytic drive (particularly in subcutaneous adipose where α₂ density is high → the rationale for 'stubborn-fat' use). Also antagonises some 5-HT receptors at higher doses. Narrow safety window — supplements commonly contain higher-than-labelled concentrations.

Half-Life (t½)

PO: 0.6h

Dosing Guidelines

Target Organ Systems

Interactions