Vitamin K2 (MK-7)

Category: vitamin

Aliases: menaquinone-7, mk7

Pharmacological Mechanism

Activates osteocalcin and matrix Gla-protein; directs calcium to bone.

Half-Life (t½)

PO: 72h

Dosing Guidelines

• PO: Typical 100 mcg (Range: 90–200 mcg)

Target Organ Systems

• musculoskeletal

Pathways It Modulates

• Vitamin D receptor genomic signaling (VDR) (cofactor) — osteocalcin γ-carboxylation
• Vitamin K cycle (γ-carboxylation) (substrate) — MK-7 alias

Chemical Identifiers

• PubChem CID: 5287554
• Formula: C46H64O2
• Molecular weight: 649 g/mol
• InChIKey: RAKQPZMEYJZGPI-LJWNYQGCSA-N
• SMILES: CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C

References

• PMID 23140417