Vigabatrin

Category: pharmacological

Aliases: Sabril

Pharmacological Mechanism

Irreversible GABA-aminotransferase (GABA-T) inhibitor — raises CNS GABA. Approved for refractory complex partial seizures + infantile spasms. Permanent visual field constriction in ~30% mandates ophthalmologic monitoring → REMS program.

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 1500mg (Range: 500 - 3000 mg)

Target Organ Systems

• nervous