Vigabatrin

Category: pharmacological

Aliases: Sabril

Pharmacological Mechanism

Irreversible GABA-aminotransferase (GABA-T) inhibitor — raises CNS GABA. Approved for refractory complex partial seizures + infantile spasms. Permanent visual field constriction in ~30% mandates ophthalmologic monitoring → REMS program.

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 1500 mg (Range: 500–3000 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• GABA-A receptor signaling (inhibitor) — GABA-T (irreversible)

Chemical Identifiers

• PubChem CID: 5665
• Formula: C6H11NO2
• Molecular weight: 129.16 g/mol
• InChIKey: PJDFLNIOAUIZSL-UHFFFAOYSA-N
• SMILES: C=CC(CCC(=O)O)N

References

• PMID 2757905