Vecuronium

Category: pharmacological

Aliases: Norcuron

Pharmacological Mechanism

Aminosteroid non-depolarizing neuromuscular blocker — competitive nicotinic ACh antagonist. Intermediate-acting (~30 min). Hepatic + biliary clearance — accumulates in liver failure.

Half-Life (t½)

IV: 1.5h

Dosing Guidelines

• IV: Typical 0.1 mg (Range: 0.08–0.1 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• Neuromuscular junction blockade + reversal (inhibitor) — nAChR (non-depolarizing)
• Nicotinic ACh receptor pharmacology (inhibitor) — NMJ non-depolarizing

Chemical Identifiers

• PubChem CID: 39765
• Formula: C34H57N2O4+
• Molecular weight: 557.78 g/mol
• InChIKey: BGSZAXLLHYERSY-XQIGCQGXSA-N
• SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1N4CCCCC4)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C

References

• PMID 2875724