Valsartan

Category: pharmacological

Aliases: Diovan

Pharmacological Mechanism

AT1 receptor blocker — no active metabolite (unlike losartan). Largely unchanged renal clearance; minimal CYP metabolism → fewer DDIs. Component of sacubitril/valsartan (Entresto) for HFrEF.

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 160 mg (Range: 40–320 mg)

Target Organ Systems

• renal

Pathways It Modulates

• Renin-angiotensin-aldosterone axis (inhibitor) — AT1 receptor

Chemical Identifiers

• PubChem CID: 60846
• Formula: C24H29N5O3
• Molecular weight: 435.52 g/mol
• InChIKey: ACWBQPMHZXGDFX-QFIPXVFZSA-N
• SMILES: CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O

References

• PMID 8242249