Valproate

Category: pharmacological

Aliases: Valproic acid, Depakote

Pharmacological Mechanism

GABA-mimetic — raises CNS GABA via GABA-T inhibition; also blocks voltage-gated Na+ channels and modulates Ca²⁺. Broad-spectrum antiseizure + bipolar + migraine prophylaxis. Strong CYP2C9 inhibitor + UGT inhibitor (raises lamotrigine 2×). Teratogenic (NTDs); mitochondrial toxicity in young children.

Half-Life (t½)

PO: 14h, IV: 14h

Dosing Guidelines

Target Organ Systems

Interactions