Valganciclovir

Category: pharmacological

Aliases: Valcyte

Pharmacological Mechanism

L-valyl ester prodrug of ganciclovir — first-pass valine hydrolysis improves oral F to ~60%. Same anti-CMV mechanism. Standard outpatient CMV prophylaxis post-transplant.

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 900mg (Range: 450 - 900 mg)

Target Organ Systems

• digestive
• immune-hematologic