Category: peptide
Aliases: Trelstar, Decapeptyl, Pamorelin
Decapeptide GnRH analog — D-Trp⁶ substitution stabilises against pituitary peptidases. Like leuprolide, an initial LH/FSH/testosterone flare (clinically relevant in prostate cancer — pre-treat with anti-androgen) transitions to chronic pituitary GnRH-R desensitisation and castrate gonadal steroids within ~3–4 weeks. Depot microsphere / embonate salt formulations provide 1, 3, or 6 month durations of action.
IM: 4h