Trandolapril

Category: pharmacological

Aliases: Mavik

Pharmacological Mechanism

ACE inhibitor prodrug — converted to trandolaprilat. Long half-life supports once-daily dosing. Used in hypertension + post-MI heart failure.

Half-Life (t½)

PO: 24h

Dosing Guidelines

• PO: Typical 4 mg (Range: 1–8 mg)

Target Organ Systems

• cardiovascular

Pathways It Modulates

• Bradykinin / kallikrein-kinin system (inhibitor) — ACE
• Renin-angiotensin-aldosterone axis (inhibitor) — ACE

Chemical Identifiers

• PubChem CID: 5484727
• Formula: C24H34N2O5
• Molecular weight: 430.54 g/mol
• InChIKey: VXFJYXUZANRPDJ-WTNASJBWSA-N
• SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O

References

• PMID 7527100