Tolterodine

Category: pharmacological

Aliases: Detrol

Pharmacological Mechanism

Bladder-preferential M3 muscarinic antagonist — designed for higher detrusor selectivity vs salivary gland. Active 5-OH metabolite via CYP2D6. Slightly cleaner anticholinergic profile than oxybutynin, but still meaningful Beers-list concerns.

Half-Life (t½)

PO: 2h

Dosing Guidelines

• PO: Typical 4mg (Range: 1 - 4 mg)

Target Organ Systems

• digestive
• renal