Tolnaftate

Category: topical

Aliases: Tinactin

Pharmacological Mechanism

Thiocarbamate antifungal — squalene epoxidase inhibitor. OTC topical for tinea pedis, cruris. Effective only against dermatophytes (not Candida). One of the oldest OTC antifungals (1965).

Half-Life (t½)

TD: 12h

Dosing Guidelines

• TD: Typical 10mg (Range: 10 - 30 mg)

Target Organ Systems

• integumentary
• immune-hematologic