Tobramycin

Category: pharmacological

Pharmacological Mechanism

Aminoglycoside with anti-pseudomonal activity slightly stronger than gentamicin. Inhaled formulation (TOBI) for chronic Pseudomonas suppression in cystic fibrosis. Same nephro / oto toxicity profile.

Half-Life (t½)

IV: 2h

Dosing Guidelines

• IV: Typical 240mg (Range: 80 - 500 mg)

Target Organ Systems

• renal
• immune-hematologic