Tiotropium

Category: pharmacological

Aliases: Spiriva

Pharmacological Mechanism

Long-acting muscarinic antagonist (LAMA) — quaternary ammonium derivative of ipratropium with M3 receptor kinetic selectivity (slow dissociation from M3 vs M2 → 24h dosing). Cornerstone COPD maintenance therapy; also approved for severe asthma.

Half-Life (t½)

INH: 27h

Dosing Guidelines

• INH: Typical 0.018mg (Range: 0.0025 - 0.018 mg)

Target Organ Systems

• respiratory