Category: pharmacological
Aliases: Stablon, Coaxil, tianeptine sodium, Tatinol
An atypical antidepressant that, unusually, acts as an efficacious agonist at the µ-opioid receptor (and a low-potency full δ-opioid agonist) — now understood to underlie both its mood effects and its abuse liability ("gas station heroin"). It also modulates glutamatergic transmission and reverses stress-induced hippocampal remodeling. At supratherapeutic doses the opioid agonism produces euphoria, tolerance, dependence, and a classic opioid withdrawal syndrome.
PO: 2.5h
PubChem CID 68870 (free acid; marketed sodium salt ≈459 g/mol). PK: Salvadori 1990 (PMID:2341111) verbatim eliminated "with a half-life of 2.5 +/- 1.1 h". Inactive at KOR per the same paper.