Teriparatide

Category: peptide

Aliases: PTH(1-34), Forteo

Pharmacological Mechanism

Active N-terminal 34-residue fragment of PTH. Daily intermittent dosing produces ANABOLIC bone effect (osteoblast > osteoclast activation) — opposite to chronic elevated PTH in hyperparathyroidism which drives resorption. Activates PTH1R on osteoblasts → RUNX2 / osteocalcin / type-I collagen production. Reduces vertebral + non-vertebral fracture risk 50–70%. Black-box for osteosarcoma (rat signal, rare in humans).

Half-Life (t½)

SC: 1h

Dosing Guidelines

• SC: Typical 20 mcg (Range: 20–20 mcg)

Target Organ Systems

• endocrine
• musculoskeletal

Pathways It Modulates

• Bone remodeling (activator) — PTH-R1 (recombinant PTH 1-34)
• cAMP / PKA second-messenger signaling (activator) — PTH-R1 (Gs/Gq)

Chemical Identifiers

• PubChem CID: 16133850
• Formula: C181H291N55O51S2
• Molecular weight: 4118 g/mol
• InChIKey: OGBMKVWORPGQRR-UMXFMPSGSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC5=CNC=N5)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)N

References

• PMID 11346808