Tasimelteon

Category: sleep

Aliases: Hetlioz

Pharmacological Mechanism

Melatonin MT1/MT2 dual receptor agonist with ~2× preference for MT2 (the SCN circadian receptor). FDA approved for non-24-hour sleep-wake disorder in totally blind patients.

Half-Life (t½)

PO: 1.3h

Dosing Guidelines

• PO: Typical 20mg (Range: 20 - 20 mg)

Target Organ Systems

• nervous