Tamsulosin

Category: pharmacological

Aliases: Flomax

Pharmacological Mechanism

α1A-adrenergic-preferring blocker — uroselective (vs vascular) → BPH symptom relief without BP drop. Modified-release once-daily dosing. CYP3A4 + CYP2D6 substrate. "Floppy iris syndrome" complicates cataract surgery.

Half-Life (t½)

PO: 14h

Dosing Guidelines

• PO: Typical 0.4 mg (Range: 0.4–0.8 mg)

Target Organ Systems

• digestive
• reproductive

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — α1A (uroselective)

Chemical Identifiers

• PubChem CID: 129211
• Formula: C20H28N2O5S
• Molecular weight: 408.51 g/mol
• InChIKey: DRHKJLXJIQTDTD-OAHLLOKOSA-N
• SMILES: CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N

References

• PMID 21496064
• PMID 9489594
• PMID 11026539