Tacrolimus (topical)

Category: topical

Aliases: Protopic

Pharmacological Mechanism

Topical calcineurin inhibitor — binds FKBP-12 → blocks calcineurin-dependent T cell activation locally in skin. Steroid-sparing for atopic dermatitis, especially face / eyelid where steroid atrophy is concerning. FDA black-box for theoretical lymphoma risk; epidemiologic signal weak.

Half-Life (t½)

TD: 10h

Dosing Guidelines

• TD: Typical 1mg (Range: 0.3 - 1 mg)

Target Organ Systems

• musculoskeletal
• integumentary
• immune-hematologic