Succinylcholine

Category: pharmacological

Aliases: Anectine

Pharmacological Mechanism

Depolarizing neuromuscular blocker — sustained nicotinic ACh receptor activation → fasciculations → flaccid paralysis. Fastest onset of any NMB (~30 sec). Hyperkalemia risk in burns, denervation, prolonged immobility. Trigger for malignant hyperthermia.

Half-Life (t½)

IV: 0.05h

Dosing Guidelines

• IV: Typical 1.5mg (Range: 1 - 2 mg)

Target Organ Systems

• nervous