Category: peptide
Aliases: SS-31, Bendavia, MTP-131
Aromatic-cationic tetrapeptide (D-Arg-2',6'-dimethyl-L-Tyr-L-Lys-L-Phe-NH₂) that selectively concentrates at the inner mitochondrial membrane via cardiolipin binding. Stabilises cardiolipin-cytochrome-c complexes → preserves electron-transport-chain supercomplex integrity under stress. Proposed indications: primary mitochondrial disease (Barth syndrome), heart failure, age-related mitochondrial dysfunction.