Spironolactone

Category: pharmacological

Aliases: Aldactone

Pharmacological Mechanism

Aldosterone receptor antagonist (mineralocorticoid receptor) — K+-sparing diuretic; also weak androgen receptor antagonist (used off-label for acne, female-pattern hair loss, PCOS). Hyperkalemia risk; gynecomastia from anti-androgen activity.

Half-Life (t½)

PO: 1.5h

Dosing Guidelines

• PO: Typical 50mg (Range: 25 - 200 mg)

Target Organ Systems

• endocrine
• renal
• reproductive
• integumentary