Sotalol

Category: pharmacological

Aliases: Betapace

Pharmacological Mechanism

Class III antiarrhythmic + non-selective β-adrenergic blocker. Prolongs cardiac action potential via IKr blockade (class III) on top of β-blockade. Used for AF rhythm control + ventricular arrhythmias. QT prolongation requires inpatient initiation in many practices.

Half-Life (t½)

PO: 12h, IV: 12h

Dosing Guidelines

• PO: Typical 160mg (Range: 80 - 320 mg)

Target Organ Systems

• cardiovascular