Sotalol

Category: pharmacological

Aliases: Betapace

Pharmacological Mechanism

Class III antiarrhythmic + non-selective β-adrenergic blocker. Prolongs cardiac action potential via IKr blockade (class III) on top of β-blockade. Used for AF rhythm control + ventricular arrhythmias. QT prolongation requires inpatient initiation in many practices.

Half-Life (t½)

PO: 12h, IV: 12h

Dosing Guidelines

• PO: Typical 160 mg (Range: 80–320 mg)

Target Organ Systems

• cardiovascular

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — β1 + β2 (non-selective) + IKr block
• Cardiac action potential (inhibitor) — β + IKr (class III)

Chemical Identifiers

• PubChem CID: 5253
• Formula: C12H20N2O3S
• Molecular weight: 272.36 g/mol
• InChIKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N
• SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O

References

• PMID 20562595
• PMID 15655528