Sorafenib

Category: pharmacological

Aliases: Nexavar

Pharmacological Mechanism

Multi-kinase inhibitor — BRAF, VEGFR, PDGFR, c-Kit, FLT3, RET. Used for hepatocellular carcinoma + advanced renal cell carcinoma + radioactive-iodine refractory thyroid cancer. Hand-foot skin reaction + hypertension common.

Half-Life (t½)

PO: 30h

Dosing Guidelines

• PO: Typical 800mg (Range: 200 - 800 mg)

Target Organ Systems

• cardiovascular
• endocrine
• digestive
• renal
• integumentary