Sofosbuvir

Category: pharmacological

Aliases: Sovaldi

Pharmacological Mechanism

HCV NS5B nucleotide polymerase inhibitor — uridine analog phosphorylated to active triphosphate, a chain-terminator for HCV RNA polymerase. Backbone of pan-genotypic HCV cure regimens (typically combined with NS5A inhibitor).

Half-Life (t½)

PO: 0.5h

Dosing Guidelines

• PO: Typical 400mg (Range: 400 - 400 mg)

Target Organ Systems

• immune-hematologic